that demonstrated ethanol administration at the dose of 1.8 g/kg via intraperitoneal for 14 days caused neurodegeneration in the cerebral cortex. Goodlett CR, Horn KH, Zhou FC. The prepared slides were observed under light microscope (Olympus BX41 Japan). It likes shade, and can be grown from bright shade to dark shade. They were kept under standard laboratory conditions in a 12 h light/dark cycle with food and water provided ad libitum. She is known worldwide as The Cosmetics Cop and creator of Paulaâs Choice Skincare. Springer Nature. Google Scholar. Microscopic structures of the brain (cerebellum and cortex cerebrum) from normal, ethanol, 200 mg/kg + ethanol, and 400 mg/kg + ethanol groups were observed as presented in Figs. The animals were randomly divided into four groups with six rats in each group. Values are expressed as mean ± SEM. Wattanathorn J, Phunchago N, Muchimapura S, Thukhum-Mee W, Chaisiwamongkol K, Kaewrueng W, Wongareonwanakij S. Mulberry fruit mitigates alcohol neurotoxicity and memory impairment induced by chronic alcohol intake. Arch Biochem Biophys. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. SOD is an antioxidant enzyme that catalyzes the conversion of anion superoxide (O2•¯) to oxygen (O2) and hydrogen peroxide (H2O2). Neural Plast. Alcohol teratogenesis: mechanisms of damage and strategies for intervention. Article Data normality and homogeneity were determined using Shapiro-Wilk and Levine test. Haorah J, Ramirez SH, Floreani N, Gorantla S, Morsey B, Persidsky Y. Koga AY, Beltrame FL, Pereira AV. Z. zerumbet ethyl-acetate extract also contains flavonoid glycoside, a derivative of kaempferol that is high in antioxidant activities . Evaluation of protein oxidation in brain regions during ethanol withdrawal under the influence of ginger extract treatment prior to abstinence from chronic ethanol consumption. However, to date, evidence on the neuroprotective effects of Z. zerumbet rhizomes is still lacking. The role of oxidative stress in fetal alcohol spectrum disorders. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). Protein carbonyl level is an indicator of protein damage that can be measured after alcohol consumption. J Zhejiang Univ Sci B. Zingiber zerumbet. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). Z. zerumbet extract at 400 mg/kg dose gave a better protective effect against ethanol-induced brain damage and this may be due to the high amount of zerumbone present in the extract. Although enzymatic activities of SOD, CAT, GPx and GSH in the Z. zerumbet treated group (200 mg/kg) were increased, but the increment were non-significant. The air dried rhizomes of Z. zerumbet were soaked in n-hexane for 72 h at room temperature. PubMed Central As the brain is rich in lipid content, it has high oxygen demand and lacks antioxidant activities thus very susceptible to oxidative stress as the brain easily undergo redox-reaction leading to radicals formation . â¦ California Privacy Statement, 2011;67:209–25. Note the number and shape of neuron cells. Lipids are biomolecules that often become the target of oxidative stress and its oxidation will produce many secondary products such as MDA. GPx enzyme activity was assayed according to the procedure described by Paglia & Valentine  based on the oxidation rate of glutathione (GSH) by H2O2 in the presence of GPx. Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. (N-Neuron cell). Google Scholar. 2011;2:1–23. Anal Biochem. This useful and medicinal Polynesian â¦ Scientific Name: Zingiber zerumbet Synonym: Amomum zerumbet Common Names: Shampoo Ginger, Bitter Ginger, 'Awapuhi, 'Awapuhi kuahiwi, Pinecone Ginger, Wild Ginger Plant Characteristics. Rev Bras. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. EXTRACT OF ZINGIBER ZERUMBET and ZINGIBER ZERUMBET EXTRACT. ROS produced by ethanol exposure for 14 days probably deactivated both GPx and GSH enzyme activities . In addition, an increase in the antioxidant activity can be described as an adaptive response to excessive ROS . PubMed Google Scholar. Zingiber zerumbet (L.) Smith: a review of its Ethnomedicinal, chemical, and pharmacological uses. Article Effect of aqueous extract of ginger on acetylcholine in brain and it’s a possible role in learning and memory during ethanol withdrawal. Kruk-Slomka M, Boguszewska-Czubara A, Slomka T, Budzynska B, Biala G. Correlations between the memory-related behavior and the level of oxidative stress biomarkers in the mice brain, provoked by an acute administration of CB receptor ligands. 2013;1(3):48–55. Zingiber aromaticum Valeton. Article 2012;7(3):81–8. Zingiber zerumbet has been traditionally used as an anti-inflammation and antioxidant agent. Zingiber zerumbetis widely used as therapeutic agent in traditional medicine and is reported to exert antioxidant activities. One-way analysis of variance (ANOVA) and post-hoc Tukey test were used to compare means between groups. Oxidative stress occurs when oxidants and antioxidants are in imbalance  either caused by excessive ROS or antioxidant system dysfunction . Privacy It also acts as a nucleophilic scavenger of toxic compounds and as a substrate in the reaction of other antioxidants (GPx uses GSH as a cofactor) . Crews FT, Nixon K. Mechanisms of neurodegeneration and regeneration in alcoholism. This indicates that the amount of antioxidant compounds present in Z. zerumbet contributes significantly to its antioxidant property . Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient, 0 studies in PubMed science library may include information on the toxicity of this chemical. The extract of Z. zerumbet was given once daily by oral gavage, 30 min prior to ethanol exposure via intraperitoneal route for 14 consecutive days. We would like to thank our colleagues from Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia who provided insight and expertise that greatly assisted the research. Gandhi S, Abramov AY. Neuron cells in in the cerebral cortex undergo necrosis with pyknotic characteristic such as darken nucleus and lost its morphology. Brain Res Dev Brain Res. Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. Aoyama K, Watabe M, Nakaki T. Regulation of neuronal glutathione synthesis. 2003;25(1):1–9. Besides that, protein is also one of the targets of ROS and its oxidation will cause protein to lose its functions. The rhizomes of Z. zerumbet are used to treat ulcerative colitis  to cure dyspepsia wound, hemorrhoids, and stomach discomfort . Thus, Z. zerumbet extract is proven not only to increase the antioxidant enzyme activities in the liver and kidney but also in the brain. Neurotoxicol Teratol. The released protein carbonyl compounds were measured at the wavelength of 375 nm. Rains JL, Jain SK. 1998;105(2):159–66. 2012;4(4):136–45. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Z. zerumbet extract protects against ethanol-induced brain damage via its antioxidant properties. In the study, decreased level of GSH has been observed in paracetamol-treated group, as excess generation of free radical species lead to oxidative stress condition with subsequent depletion in GSH level. THM and KH prepared and analyzed the herbs. Human anterior cingulate cortex neurons encode cognitive and emotional demands. The concoction of Zingiber zerumbet rhizomes is normally drunk to treat indigestion, stomachache, fever and worm infestation. 2008;108(3):227–38. 2007; https://doi.org/10.1186/1475-2867-7-4. EXTRACT OF ZINGIBER ZERUMBET and ZINGIBER ZERUMBET EXTRACT. By using this website, you agree to our PubMed Central THM, NE, MNN analyzed the data and wrote the manuscript. Saan bibilhin ang Zingiber Zerumbet Extract? The dissolved ZZRE was diluted in 95 mL PBS. Mol Asp Med. 2002;26(4):547–57. However, administration of Z. zerumbet extract appeared to reduce oxidative stress induced by ethanol as evidenced by increased level of GSH in the brain. This work was financially funded by Ministry of Higher Education Fundamental Research Grant Scheme (FRGS/1/2013/SKK01/UKM/02/1) and Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, UKM. This was shown by increased in both antioxidant SOD and GSH level and reduction of both homogenate and plasma MDA, plasma protein carbonyl, and renal advanced oxidation protein product (AOPP) than those in the paracetamol induced group . Search by keywords . Cerebellum is responsible for coordinating muscle activities and maintaining body posture and balance. SOD activity was assayed based on the procedure described by Beyer & Fridovich . Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Administration of ethanol for 14 days induced oxidative stress as evidenced by a significant reduction (p < 0.05) of SOD, CAT and GPx enzyme activities (Fig. Abdul Hamid Z, Budin SB, Wen Jie N, Hamid A, Husain K, Mohamed J. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. Wudpecker J Food Technol. Although it is metabolized mainly in the liver, it also causes toxic effects to the brain . This process was repeated three times. Obernier JA, Bouldin TW, Crews FT. Phachonpai W, Wattanathorn J, Wannanon P, Thipkaew C, Sripanidkulchai B, Muchimapura S. Coscinium Fenestratum protects against ethanol-induced neurodegeneration in adult in rat brain. The ability of Z. zerumbet to protect brain tissues from lipid peroxidation and protein oxidation is in agreement with Hamid et al. Anti-Microbial - In this study they investigated antimicrobial effects of ethanolic extract of Zingiber zerumbet (Z. zerumbet) (L.) Smith and its chloroform and petroleum ether soluble fractions against pathogenic bacteria and fungi. Zingiber Zerumbet Plant Extract Wuhan HHD 100% Pure Natural Plant Extract Of Zerumbone Zingiber Zerumbet Extract US $10.00-$80.00 / â¦ Free Radic Biol Med. Tissue sulfhydryl groups. Both doses of extracts also significantly increased the level of serum superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities as well as glutathione (GSH) level (p < 0.05). The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. Used in pharmaveutical field, 3. This family of ginger was found to reduce the brain infarct volume and decrease oxidative stress in the cerebral cortex and hippocampus. One brain region that is particularly sensitive to early ethanol exposure is the cerebellum. The rhizomes of Z. zerumbet, particularly, have been regularly used as food flavouring and appetizer in various Malays' cuisines while the rhizomes extracts have been used in Malay traditional medicine to treat various types of ailments (e.g., inflammatory- and pain â¦ Food Chem.  and Abdul Hamid et al. A significant increased (p < 0.05) level of MDA was observed in brain samples of ethanol-induced group as compared to the normal group. Oral administration of aqueous ginger extract during chronic ethanol ingestion significantly ameliorates ethanol-induced protein peroxidation . 2012. About the Experts. About SkinDeep®/Methodology Furthermore, the antioxidant activity of Z. zerumbet and its constituents were also found to be able to eliminate free radicals and its antioxidant activities were increased in a dose-dependent manner . In Northern climates, It can be dug up, and stored in a paper bag with some sawdust or dry â¦ All procedures were approved by the Universiti Kebangsaan Malaysia Animal Ethics Committee (UKMAEC), Laboratory Animal Resource Unit, Faculty of Medicine, UKM, Jalan Raja Muda Abdul Aziz, Kuala Lumpur. Zingiber Zerumbet Extract Official CosIng Information Products with Zingiber Zerumbet Extract. The crude extracts were then stored at 4 °C until tested for bioassay. Zerumbet zingiber T.Lestib. The ‘French paradox’ and beyond: neuroprotective effects of polyphenols. Methods Enzymol. Zingiber zerumbet (Smith) belongs to the family Zingiberaceae and is locally known as “lempoyang” . All authors read and approved the final manuscript. Herbal substance(s) (binomial scientific name of the plant, including plant part) Significant brain damage in adults is found in limbic association regions and in these regions, dark cell degeneration, a necrotic cell death is the predominant form of neuronal death . However, administration of ethyl-acetate Z. zerumbet extract at 400 mg/kg showed better protective effects on the ethanol-induced brain damage as shown with higher levels of SOD, CAT, GPx and GSH in the brain homogenate as compared to 200 mg/kg dose. Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney. https://doi.org/10.1186/s12906-018-2161-5, DOI: https://doi.org/10.1186/s12906-018-2161-5. 4). Effects of Z. zerumbet extract on serum superoxide dismutase (a), brain superoxide dismutase (b), serum catalase (c), brain catalase (d), serum glutathione peroxidase (e), brain glutathione peroxidase (f) activities and brain glutathione level (g). GPx enzyme is responsible for detoxifying H2O2 by converting it to H2O in which GSH acts as an electron donor in this reaction . Zingiber Zerumbeti ekstrakti tootjad Bolise'ist. For 400 mg/kg Z. zerumbet treated groups, there was a significant increment (p < 0.05) in the GSH level but 200 mg/kg Z. zerumbet treated group showed no significant difference (p > 0.05) compared to the ethanol group. In contrast, treatment with Z. zerumbet extract (200 mg/kg & 400 mg/kg) reduced the MDA and protein carbonyl levels in the brain. Increased in the lipid peroxidation is represented by an increase in the MDA concentration, which is a good biomarker for oxidative stress in the brain . Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke’s encephalopathy. And/Or analysed during the current study available from the corresponding author on reasonable.... Nm wavelength neuronal loss in functional zones of the plant extract was potential. Effects of Z. zerumbet extract administration increased the activities of SOD and GSH enzyme [. 1, 12 ] cortex consists of three levels ; molecular layer granular! Zainal Z, Sirat H, Rinna A. glutathione: overview of its protective,... Responsible for coordinating muscle activities and maintaining body posture and balance reduction of level. Provided intracellular protection mechanism to remove free radicals from toxic agents [ 33 ] development... Evaluated in vitroantioxidant potential of Z. officinale extract was found to reduce the brain ethanol/ethyl-acetate that would remove lipids the. C, Amsellem S, Nalabothu p, Sandiford S, Nalabothu,... Brain [ 2 ] cortex neurons encode cognitive and emotional demands ruslay S, Abas F, Shaari K Sulochanamma. And correlates with motor performance produced by ethanol Calabrese V. Vitamin E and neurodegenerative disorders associated with oxidative in. Against cisplastin-induced nephrotoxicity by blocking the MDA formation [ 33 ] and without Wernicke ’ S a role... 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